ABSTRACT
Primary central nervous system lymphoma [PCNSL] is an extremely rare condition in childhood. We report the first case of PCNSL in a child in Iran. A nine-year-old boy was referred to Mofid Hospital with the history of headache of four months and seizure of 2 months duration. Magnetic resonance imaging of the brain revealed a hyper-intense lesion in left fronto-parietal area with secondary satellite lesions. Biopsy of the brain mass was performed. Pathologic findings showed brain lymphoma and immunohistochemistry confirmed this diagnosis. The treatment started with intrathecal and systemic chemotherapy in combination with radiotherapy
Subject(s)
Humans , Male , Central Nervous System Neoplasms/diagnosis , Child , Headache , Seizures , Magnetic Resonance Imaging , Immunohistochemistry , Tomography, X-Ray ComputedABSTRACT
Acute disseminated encephalomyelitis [ADEM] and Guillain-Barre syndrome [GBS] are both para infectious demyelinating disorders. While ADEM almost always affects the CNS, GBS affects the PNS. The combined demyelinating process - demyelination of both upper motor neuron [UMN] and lower motor neuron [LMN] - occurs very rarely. Here we report a case of severe combined peripheral and central demyelination, in which the former disorder was preceded by the latter